MTHFR & Methylation Disorders

Folate-rich foods (dark leafy greens, asparagus, Brussels sprouts, lentils, avocado) - dietary folate better than synthetic folic acid for MTHFR, B12 rich foods (grass-fed red meat, wild fish, organ meats, eggs, shellfish), vitamin B6 foods (wild salmon, poultry, potatoes, bananas), avoid synthetic folic acid (fortified foods, cheap supplements - can block folate receptors in MTHFR), beetroot for betaine (TMG), adequate methionine from animal protein, limit alcohol (depletes B vitamins and impairs methylation), reduce homocysteine-raising foods if elevated (excess coffee).

Avoid folic acid supplements and fortified foods (breads, cereals), reduce toxin exposure (methylation critical for detoxification), manage stress (depletes methylation), adequate sleep, avoid excess alcohol, support gut health (produces B vitamins), consider genetic counseling if planning pregnancy (folate critical for neural tube development), avoid nitrous oxide (depletes B12), if COMT mutations present manage stress and avoid high-dopamine supplements, monitor homocysteine regularly.