Loading...
Emerging DiagnosticMetabolic HealthUpload Compatible
Methylation Panel
Decode the master biochemical process behind detox, mood, and DNA repair
$300–$500
10–14 business days
Methylation panel testing measures key markers in the methylation cycle — homocysteine, SAMe, SAH, methylmalonic acid, and B-vitamin cofactors — revealing how efficiently your body is performing this critical biochemical process that affects detoxification, neurotransmitter production, DNA repair, and gene expression.
Methylation is arguably the most important biochemical process in your body. It's required for making neurotransmitters, detoxifying chemicals and hormones, repairing DNA, and controlling gene expression. When methylation is impaired, everything suffers.
What It Measures
Homocysteine (methylation bottleneck marker)
SAMe (S-adenosylmethionine — primary methyl donor)
SAH (S-adenosylhomocysteine)
SAMe-to-SAH ratio (methylation capacity)
Methylmalonic acid (B12 functional marker)
Formiminoglutamic acid (FIGLU — folate marker)
B6, B12, and folate cofactor levels
Why Gabriel Recommends It
Methylation dysfunction is at the root of countless chronic health issues: depression (can't make serotonin), fatigue (mitochondrial dysfunction), high homocysteine (cardiovascular risk), poor detoxification (can't clear estrogen or toxins), and accelerated aging (impaired DNA repair). Gabriel uses methylation panel data to identify bottlenecks in your methylation cycle and to design targeted protocols with methylated B vitamins (methylfolate, methylcobalamin), methylation cofactors (magnesium, zinc, choline), and methylation support nutrients (TMG, betaine) — personalized to your biochemistry.
What to Expect
A fasting blood draw at a local lab or specialty lab. Fast for 10–12 hours (water only). Avoid methylated B-vitamin supplements for 3–5 days before testing for baseline accuracy. Results arrive in 10–14 business days with detailed methylation cycle analysis. Upload to Gabriel for methylation optimization protocols.
How Gabriel Interprets This
Conventional practitioners read these results through a disease-focused lens — looking for what's broken. Gabriel reads them through a holistic lens — looking for what's out of balance and how to restore it. We see optimal ranges, not just "normal" ranges. We connect findings across all your diagnostics to reveal patterns that siloed specialists miss.
Related Conditions
$300–$50010–14 business days
Frequently Asked Questions
Methylation is a biochemical process that happens billions of times per second in your body. It's critical for DNA repair, detoxification, neurotransmitter production, immune function, and energy metabolism. Impaired methylation is linked to cardiovascular disease, depression, cancer risk, and chronic fatigue.
It typically measures homocysteine, methylmalonic acid (B12 status), folate, B12, SAMe/SAH ratio, and sometimes MTHFR genetic variants. Together, these reveal whether your methylation cycle is running efficiently or has bottlenecks that need targeted support.
MTHFR is a gene that helps convert folate into its active form (methylfolate). About 40% of the population has at least one variant. Having a variant doesn't guarantee problems, but it means you may need methylfolate instead of folic acid and should monitor homocysteine levels. Two copies of C677T is more clinically significant.
Blood methylation markers (homocysteine, B12, folate, methylmalonic acid) cost $75-150 through direct labs. MTHFR genetic testing adds $100-200. Insurance covers homocysteine and B12 with appropriate diagnosis codes.
Not sure which test is right?
Tell Gabriel your symptoms and health goals. Get personalized diagnostic recommendations backed by evidence, not guesswork.