HormonalEmerging Evidence

Angiotensin 1-7

Also known as: Ang-(1-7), A(1-7)

Protective peptide of the renin-angiotensin system with vasodilatory and anti-inflammatory effects.

Benefits

Conditions

Evidence

Preclinical studies, early clinical trials+ studies

Source

Endogenous heptapeptide, can be synthesized

Gabriel Brain Score

Strong

Overview

Protective peptide of the renin-angiotensin system with vasodilatory and anti-inflammatory effects.

Mechanism of Action

Binds Mas receptor (counterbalances ACE/Ang II pathway), vasodilation via NO/prostaglandin release, anti-fibrotic and anti-proliferative effects, reduces oxidative stress, anti-inflammatory via reduced cytokines, cardioprotective and neuroprotective actions.

Key Benefits

✓Cardiovascular protection
✓Vasodilation and blood pressure reduction
✓Anti-fibrotic effects
✓Neuroprotection
✓Anti-inflammatory
✓Metabolic benefits (improved insulin sensitivity)

Clinical Applications

HypertensionHeart failureFibrotic diseasesMetabolic syndromeNeurodegenerative diseasesCOVID-19 complications (investigational)

Dosing Guidelines

Subcutaneous or intravenous

Typical DoseResearch protocols vary

FrequencyVariable

DurationInvestigational

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Emerging

Studies

Preclinical studies, early clinical trials

Summary

Strong preclinical evidence for cardiovascular and metabolic protection. ACE2/Ang-(1-7)/Mas axis well-characterized. Human clinical trials emerging. Interest increased due to ACE2/COVID-19 connection.

Safety Information

Potential Side Effects

•Unknown in humans (limited data)
•Theoretical hypotension

Contraindications

Under investigation

Interactions

⚠May interact with ACE inhibitors and ARBs

Quick Facts

CategoryHormonal

SourceEndogenous heptapeptide, can be synthesized

Legal StatusInvestigational, not approved

Gabriel Brain Score

85/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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