Growth HormoneModerate Evidence

Ipamorelin

Also known as: NNC 26-0161

Selective ghrelin mimetic that triggers rapid growth hormone release without affecting cortisol or prolactin.

Benefits

Conditions

Evidence

Clinical trials, safety studies in adults+ studies

Source

Synthetic ghrelin mimetic pentapeptide

Gabriel Brain Score

Moderate

Overview

Selective ghrelin mimetic that triggers rapid growth hormone release without affecting cortisol or prolactin.

Mechanism of Action

Binds ghrelin receptor (GHS-R1a) on pituitary cells, triggers rapid GH release without hypothalamic involvement, no cortisol or prolactin elevation, synergizes with CJC-1295 for optimal pulsatile GH patterns.

Key Benefits

✓Rapid GH pulse induction
✓No cortisol or prolactin spike
✓Improved body composition
✓Enhanced recovery
✓Better sleep
✓Synergistic with GHRH analogs

Clinical Applications

Growth hormone deficiencyAge-related GH declineAthletic recoveryBody composition goalsSleep quality improvement

Dosing Guidelines

Subcutaneous injection

Typical Dose200-300 mcg

Frequency1-3 times daily (often before bed)

Duration8-12 weeks

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Moderate

Studies

Clinical trials, safety studies in adults

Summary

Clinical evidence for selective GH release. Good safety profile with minimal side effects. Often combined with CJC-1295 for synergy.

Safety Information

Potential Side Effects

•Minimal
•Increased hunger
•Water retention (mild)
•Headache

Contraindications

Active cancer
Pregnancy
Breastfeeding

Interactions

⚠Synergistic with GHRH analogs

Quick Facts

CategoryGrowth Hormone

SourceSynthetic ghrelin mimetic pentapeptide

Legal StatusResearch compound, not FDA approved

Gabriel Brain Score

79/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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