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Also known as: Palmitoyl pentapeptide-4, Pal-KTTKS
Signal peptide that stimulates collagen, elastin, and extracellular matrix production for skin rejuvenation.
Benefits
6
Conditions
5
Evidence
Multiple cosmetic clinical trials, in vitro studies+ studies
Source
Synthetic peptide
Gabriel Brain Score
Moderate
Signal peptide that stimulates collagen, elastin, and extracellular matrix production for skin rejuvenation.
Stimulates fibroblasts to produce type I and III collagen, elastin, fibronectin, proteoglycans, and glycosaminoglycans, remodels extracellular matrix, enhances skin thickness and structural integrity.
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Multiple cosmetic clinical trials, in vitro studies
Well-studied in cosmetic applications. Clinical trials show improvements in wrinkle depth and skin texture. Popular ingredient in anti-aging skincare with good evidence base.
Tripeptide-copper complex that stimulates collagen synthesis, wound healing, and skin regeneration.
Hydrolyzed collagen fragments that support skin, joint, and connective tissue health through oral supplementation.
Extended version of Argireline with enhanced potency (~30% more effective) for wrinkle reduction.