NeuroprotectiveModerate Evidence

Semax

Also known as: ACTH(4-10) analogue

Russian synthetic peptide derived from ACTH with potent nootropic and neuroprotective effects.

Benefits

Conditions

Evidence

Multiple Russian clinical trials, preclinical studies+ studies

Source

Synthetic ACTH(4-10) analogue with Pro-Gly-Pro modification

Gabriel Brain Score

Strong

Overview

Russian synthetic peptide derived from ACTH with potent nootropic and neuroprotective effects.

Mechanism of Action

Rapidly upregulates BDNF and TrkB in hippocampus, activates serotonergic and dopaminergic systems, provides neuroprotection against oxidative stress and inflammation, possible melanocortin receptor modulation, enhances neuroplasticity and cognitive function.

Key Benefits

✓Cognitive enhancement and memory improvement
✓Neuroprotection against stroke and hypoxia
✓Reduces anxiety and stress effects
✓Improves focus and attention
✓Supports recovery from brain injury
✓Antidepressant-like effects
✓Immune system modulation

Clinical Applications

Stroke and TIACognitive declineADHD and attention disordersAnxiety and stressOptic nerve diseasePost-concussion syndromeDepression

Dosing Guidelines

Intranasal drops

Typical Dose0.1-1% solution, 2-3 drops per nostril

Frequency2-3 times daily

Duration10-30 days cycles

Subcutaneous injection

Typical Dose0.5-1 mg

FrequencyOnce daily

Duration10-30 days cycles

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Moderate

Studies

Multiple Russian clinical trials, preclinical studies

Summary

Approved in Russia for stroke, cognitive disorders, and immune support. Extensive Russian research with limited Western validation. Strong preclinical neuroprotective data.

Safety Information

Potential Side Effects

•Nasal irritation
•Restlessness
•Insomnia (if taken late)
•Anxiety (at high doses)

Contraindications

Pregnancy
Breastfeeding
Severe anxiety disorders

Interactions

⚠May potentiate stimulants
⚠Possible interactions with antidepressants

Quick Facts

CategoryNeuroprotective

SourceSynthetic ACTH(4-10) analogue with Pro-Gly-Pro modification

Legal StatusApproved in Russia; research compound in most other countries

Gabriel Brain Score

88/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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