Insulin Resistance Reversal Protocol

Insulin resistance is epidemic - affecting 88% of US adults to some degree (per metabolic health biomarkers). Root cause of: Type 2 diabetes, PCOS, fatty liver (NAFLD), metabolic syndrome, cardiovascular disease, Alzheimer's ("type 3 diabetes"). Mechanism: Chronic hyperinsulinemia (from diet high in refined carbs, frequent eating) causes cells to downregulate insulin receptors (resistance). Fasting insulin is best test - >5 µIU/mL suggests early IR, >10 clearly insulin resistant. HOMA-IR calculation: (fasting insulin × fasting glucose)/405 - >2.0 is IR. Reversal strategies: Reduce insulin exposure (low-carb diet, fasting, fewer meals) + improve insulin sensitivity (exercise, weight loss, supplements). Low-carb/keto dramatically improves IR - reduces glucose load, lowers insulin. Intermittent fasting reduces meal frequency (less insulin exposure). Extended fasting even more powerful - 24-36 hour fasts deplete glycogen, reduce insulin profoundly. Berberine is star supplement - multiple RCTs showing effects comparable to metformin. Activates AMPK (cellular energy sensor), improves glucose uptake. Inositol for PCOS-related IR (see HC-003). ALA improves glucose disposal. Magnesium deficiency impairs insulin signaling (most Americans deficient). Exercise, especially resistance training, builds muscle (insulin-sensitive tissue) and improves GLUT-4 translocation. Visceral fat is insulin-resistant and pro-inflammatory - losing belly fat reverses IR. Sleep deprivation acutely causes IR (even one night of poor sleep). Continuous glucose monitor (CGM) is powerful tool - see real-time blood sugar responses to foods, identify individual triggers. IR is reversible - not a one-way street. Type 2 diabetes can be reversed in early stages with aggressive lifestyle. Fung's clinic routinely reverses T2D and eliminates medications.